2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W1121770
    DMTr-2'-O-Propargyl-rU-3'-CE-phosphoramidite
    DMTr-2'-O-propargyl-rU-3'-CE -Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Propargyl-rU-3'-CE-phosphoramidite
  • HY-178547
    DMTr-2'-O-C6-rC(Bz)-3'-CE-phosphoramidite
    DMTr-2'-O-C6-rC(Bz)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C6-rC(Bz)-3'-CE-phosphoramidite
  • HY-13548
    DL-Alanosine
    		Inhibitor
    DL-Alanosine is an amino acid analogue with antitumor activities.
    DL-Alanosine
  • HY-126160
    CB10-277
    CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma.
    CB10-277
  • HY-W700549
    DMT-dT
    DMT-dT is a nucleotide derivative.
    DMT-dT
  • HY-W014306R
    2',3'-Dideoxyuridine (Standard)
    2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3'-Dideoxyuridine (Standard)
  • HY-178651
    DNA 5-Ethynyl(TIPS)-U amidite
    DNA 5-Ethynyl(TIPS)-U amidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DNA 5-Ethynyl(TIPS)-U amidite
  • HY-B1468R
    8-Azaguanine (Standard)
    		Chemical
    8-Azaguanine (Standard) is the analytical standard of 8-Azaguanine. This product is intended for research and analytical applications. 8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.
    8-Azaguanine (Standard)
  • HY-178596
    DMTr-2'-O-Me-rU-3'-(L)-PSM-phosphoramidite
    DMTr-2'-O-Me-rU-3'-(L)-PSM-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rU-3'-(L)-PSM-phosphoramidite
  • HY-178627
    5'-O-DMTr-2'-O-TOM-rA(Ac)
    5'-O-DMTr-2'-O-TOM-rA(Ac) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-2'-O-TOM-rA(Ac)
  • HY-137649C
    Rp-2'-O-Me-CTPαS tetrasodium
    Rp-2'-O-Me-CTPαS tetrasodium is a CTP analog with a modified 2'-OH group.
    Rp-2'-O-Me-CTPαS tetrasodium
  • HY-178566
    DMTr-2'-F-dU-3'-(D)-DPSE-phosphoramidite
    DMTr-2'-F-dU-3'-(D)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-F-dU-3'-(D)-DPSE-phosphoramidite
  • HY-W098689
    Dmf-dg
    		98.0%
    Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a deoxyguanosine (dG) nucleoside protected by the dimethylaminomethylamidine (DMF) base and can be used for oligonucleotide synthesis.
    Dmf-dg
  • HY-134991A
    3'-Deoxy-GTP trisodium
    3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP trisodium inhibits DENV NS5 RdRp (IC50: 0.02 μM).
    3'-Deoxy-GTP trisodium
  • HY-W784608
    Spacer phosphoramidite 9
    Spacer phosphoramidite 9 (Spacer-9 CEP) is a monomeric raw material that can be used for nucleic acid synthesis.
    Spacer phosphoramidite 9
  • HY-108060AR
    Valopicitabine dihydrochloride (Standard)
    Valopicitabine dihydrochloride (Standard) is the analytical standard of Valopicitabine (dihydrochloride) (HY-108060A). This product is intended for research and analytical applications. Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
    Valopicitabine dihydrochloride (Standard)
  • HY-137616A
    Sp-dUTPαS tetrasodium
    Sp-dUTPαS tetrasodium is an isomer of the sulfur-containing nucleotide dUTPαS.
    Sp-dUTPαS tetrasodium
  • HY-W1121728
    3'-O-TBDMS-2'-F-dA(Bz)
    3'-O-TBDMS-2'-F-dA(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-TBDMS-2'-F-dA(Bz)
  • HY-178565
    DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-phosphoramidite
    DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-phosphoramidite
  • HY-173169
    7-Methylguanosine 5′-monophosphate
    7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a building block of nucleic acid.
    7-Methylguanosine 5′-monophosphate